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Bridging Genomes and Phenotypes: Evo-Devo, Epigenetics, and the Reshaping of Evolutionary Theory

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The Modern Synthesis, or Neo-Darwinism, forged in the mid-20th century, provided a framework for understanding evolution by integrating Darwin's theory of natural selection with Mendelian genetics and population genetics. Its core tenets emphasized the primacy of genes as the units of inheritance, random genetic mutation as the sole source of novel variation, and natural selection acting on populations as the primary engine of evolutionary change.  For decades, this gene-centric view dominated evolutionary biology. However, emerging fields, particularly Evolutionary Developmental Biology (Evo-Devo), have brought forth phenomena that challenge the sufficiency of the Neo-Darwinian framework, necessitating a broader perspective often termed the Extended Evolutionary Synthesis (EES). Evo-Devo's focus on the interplay between development and evolution, significantly bolstered by insights into epigenetic mechanisms, offers crucial contributions to ...

The epigenetic system, evo-devo, and the Extended Evolutionary Synthesis.

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This blog covers the core concepts and arguments typically involved. Integrating Development and Inheritance: The Epigenetic System, Evo-Devo, and the Case for an Extended Evolutionary Synthesis The theory of evolution, as solidified in the 20th century's Modern Synthesis (MS), provided a framework centered on genes as the primary unit of inheritance and variation. Natural selection, genetic drift, mutation, and gene flow acting on randomly generated genetic variation were seen as the principal engines of evolutionary change. However, accumulating evidence from diverse fields, particularly developmental biology and epigenetics, has prompted a call by researchers for an 'Extended Evolutionary Synthesis' (EES). This proposed extension seeks to integrate phenomena inadequately addressed or conceptualized by the MS, arguing that factors like developmental processes and non-genetic inheritance play crucial causal roles in evolution. The interc...

Shifting Timescales: How Epigenetic Inheritance Reshapes Evolutionary Thought

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For decades, the neo-Darwinian synthesis has provided the dominant framework for understanding evolution. It posits that evolution occurs through the gradual accumulation of random genetic mutations within a population, with natural selection acting upon the resulting phenotypic variations. Inheritance, in this view, is almost exclusively mediated by the DNA sequence passed from parents to offspring. This process operates on long timescales, with significant evolutionary change typically unfolding over many generations. However, the burgeoning field of epigenetics is introducing a profound challenge this picture, revealing inheritance mechanisms that operate on potentially much shorter timescales and challenging some core assumptions of the traditional model. The Long Timescale: Genetic InheritanceGenetic inheritance is the bedrock of classical evolutionary theory. It involves the transmission of genes – specific sequences of DNA – from one generatio...

Beyond the Gene: the Extended Evolutionary Synthesis

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The Modern Synthesis, a fusion of Darwinian natural selection and Mendelian genetics, has been the main emphasis in evolutionary biology for nearly a century. It trys to explains the gradual adaptation of populations through the inheritance of gene variations acted upon by environmental pressures. However, the past few decades have witnessed a surge of discoveries that challenge the completeness of this framework, leading to a vibrant debate about the need for an "Extended Evolutionary Synthesis" (EES). At the heart of this discussion lies the burgeoning field of epigenetics and its profound implications for our understanding of heredity and evolutionary change, directly confronting some of the core tenets of neo-Darwinism. Neo-Darwinism, the prevailing interpretation of the Modern Synthesis, emphasizes the gene as the primary unit of inheritance and the sole source of heritable variation. Evolution, in this view, is driven by random genetic mutations ...

Unmodern Synthesis: Developmental Hierarchies and the Origin of Phenotypes

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The paper "Unmodern Synthesis: Developmental Hierarchies and the Origin of Phenotypes" by Richard Gawne, Kenneth Z. McKenna, and H. Frederik Nijhout, published in BioEssays in 2018, presents a critical perspective on the Modern Evolutionary Synthesis (MES) and argues for a more integrated understanding of how phenotypes originate. The authors contend that while the MES has been successful in explaining the mechanisms of evolutionary change at the population genetic level, it falls short in providing a comprehensive account of the developmental processes that generate phenotypic variation, the raw material upon which natural selection acts. Gawne, McKenna, and Nijhout propose a hypothetical "Unmodern Synthesis" (UMS) as a contrasting framework. This UMS emphasizes the hierarchical nature of biological organization and the active role of developmental processes at all levels in shaping phenotypes. Unlike the gene-centric view often associated with the MES,...

The Organism in the EES

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The journal article "The Organism in Evolutionary Explanation: From Early Twentieth Century to the Extended Evolutionary Synthesis" articulates a profound challenge to the Modern Synthesis (MS) by resurrecting and re-evaluating the role of the organism in evolutionary theory. This isn't a mere tweaking of existing frameworks; it's a fundamental shift in perspective, echoing the holistic, organism-centric viewpoints that prevailed before the MS solidified its dominance. The article meticulously demonstrates how the Extended Evolutionary Synthesis (EES) seeks to dismantle the gene-centric and population-focused paradigm that characterized the MS, replacing it with a more integrated and dynamic understanding of evolutionary processes. At the heart of this challenge is the EES's insistence on restoring the organism to its rightful place as an active, influential participant in evolution, rather than a passive vessel for genetic transmission. This directly...

The Modern Synthesis aka Neo-Darwinism is not the Extended Evolutionary Synthesis

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" The summary of the state of affairs on the 150th anniversary of the Origin is somewhat shocking: in the post-genomic era, all major tenets of the Modern Synthesis fthe theory of evolution) are, if not outright overturned replaced by a new and incomparably more complex vision of the key aspects of evolution (EES). So, not to mince words , the Modern Synthesis is gone" -Eugene Koonin, an evolutionary biologist (Cited by over 270,000 evolutionary scientists.) The Extended Evolutionary Synthesis (EES) represents a significant departure from the traditional neo-Darwinian framework, also known as the Modern Synthesis . While both theories aim to explain evolutionary change, they differ fundamentally in their underlying mechanisms and the roles they assign to various biological processes. A crucial point of divergence lies in the interpretation and application of the term " evolutionary ," particularly concerning the incorporation of epigenetic mechanisms....