Beyond Neo-Darwinism: How Epigenetics and Functional "Junk" DNA Drive the Extended Evolutionary Synthesis
Neo-Darwinism, the modern synthesis of Darwinian evolution with Mendelian genetics, has long been the bedrock of our understanding of how life evolves. It posits that random mutations in DNA sequence, coupled with natural selection, drive the gradual changes we see in species over time. However, recent discoveries in epigenetics and the functionality of "junk" DNA are challenging this traditional view, leading to a new framework known as the Extended Evolutionary Synthesis (EES) . Epigenetics: Inheritance Beyond the Sequence Epigenetics refers to changes in gene expression that do not involve alterations to the underlying DNA sequence as with Neo-Darwinism. These changes, often influenced by environmental factors, can be heritable across generations. This challenges the neo-Darwinian focus on random mutations as the sole source of heritable variation. One of the key mechanisms of epigenetics is DNA methylation , where methyl groups attach to DNA, influencing ge...